Endocrine Abstracts

Bone mineral density (BMD) and bone mass are quantitative traits that are the result of the two balanced processed of bone resorption and bone formation. Often they are used as a surrogate phenotype for the diagnosis of osteoporosis, characterized by an increased fracture risk due to a decreased bone mass and deterioration of the microarchitecture of the bone.Variation in BMD is determined by both environmental and genetic factors with 50–85% of the...

The last year has definitely not been the most easy one for research in general as the COVID-19 pandemic resulted in limitations on how basic research could be performed. Despite this, it is definitely worthwhile to look back on the data that has been published over the last year. During this presentation, I will highlight some publications that, for one or another reason, can be considered of major importance for or impact on the bone field. This selection was made by searchi...

Objective: NPY2R is a G-protein-coupled receptor which is highly expressed in orexigenic NPY/AGRP neurons within the arcuate nucleus, a major integrator of appetite control in the hypothalamus. Genetic evidence coming from animal and association studies, has identified NPY2R as a candidate gene for obesity. Therefore we have designed an extensive mutation and CNV-analysis investigating the prevalence of genetic and structural variation in NPY2R.Design an...